Isoflurane Inhibits the Neurotransmitter Release Machinery
نویسندگان
چکیده
منابع مشابه
Isoflurane inhibits the neurotransmitter release machinery.
Despite their importance, the mechanism of action of general anesthetics is still poorly understood. Facilitation of inhibitory GABA(A) receptors plays an important role in anesthesia, but other targets have also been linked to anesthetic actions. Anesthetics are known to suppress excitatory synaptic transmission, but it has been difficult to determine whether they act on the neurotransmitter r...
متن کاملIsoflurane inhibits the neurotransmitter release machinery 7 8 9 10
43 44 Despite their importance, the mechanism of action of general anesthetics is still 45 poorly understood. Facilitation of inhibitory GABAA receptors plays an important role in 46 anesthesia but other targets have also been linked to anesthetic actions. Anesthetics are 47 known to suppress excitatory synaptic transmission, but it has been difficult to determine 48 whether they act on the neu...
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Synapses have a long history in science. Synapses were first functionally demonstrated by Emil duBois-Reymond (1818–1896), were morphologically identified by classical neuroanatomists such as Rudolf von Kölliker (1817–1905) and Santiago Ramon y Cajal (1852–1934), and named in 1897 by Michael Foster (1836– 1907). Although the chemical nature of synaptic transmission was already suggested by duBo...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2009
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00252.2009